His work stems from an unrelenting curiosity that leads him to experiment with diverse media, methods and techniques across painting, public art, internet art, happenings, technology, chemistry and sculpture. He employs these methods to produce critically astute and sociologically engaged works that deal with the here and now, through a deep connection to cultural history. 

Despite being renowned globally for his challenging solo exhibitions in New York, Milan, Los Angeles, Hong Kong and London, Semple remains a hermetic cult figure working from a secluded studio on the south coast of England.